Muva nje, izikhondlakhondla zikagwayi ezimbili ezinkulu, i-PMI ne-BAT, ngokulandelana kwazo zishicilele amaphepha ocwaningo kumajenali ezokwelapha aphezulu emhlabeni jikelele.Imiphumela yocwaningo ibonisa ukuthi imikhiqizo emisha kagwayi efana ne-e-cigarettes nemikhiqizo engashisi ayinabungozi futhi inobuthi kunogwayi wendabuko, futhi inganciphisa kakhulu umthelela ohlelweni lokuphefumula.umonakalo.
Njengoba ukuqwashisa kwabantu ngezingozi zokubhema kukhula, ugwayi we-elekthronikhi uya ngokuya uqashelwa njengokuthatha indawo kagwayi, kodwa imiphumela yesikhathi eside yengxube ye-flavour ye-e-cigarette kanye nentuthu kagwayi kubabhemi kusazobhekwa kabanzi.Muva nje, u-PMI uPhilip Morris International ushicilele umbiko wocwaningo "Ukuhlolwa kobuthi bokuphefumula kwentuthu kagwayi kanye nama-aerosols avela ezixubeni zokunambitheka: isifundo seviki le-5 kumagundane we-A/J" ku-British Journal of Toxicology "Journal of Applied Toxicolog", echaza imininingwane. zezihloko ezihlobene Izinyathelo zocwaningo kanye nemiphumela.
Ocwaningweni, amagundane abesilisa angama-87 kanye namagundane ayi-174 angama-nulliparous nakhulelwe abelwa amaqembu okuhlola ayi-9, futhi ahlolwa emoyeni, entuthuni kagwayi, kanye nama-aerosol e-e-cigarette anezingxube ezintathu ezihlukene zama-flavour, aphezulu, aphakathi, naphansi. .Ukuchayeka kufika emahoreni ayi-6 ngosuku, izinsuku ezi-5 ngeviki, amasonto ama-5 kwalandelwa i-necropsy, isisindo somzimba kanye nokuhlolwa kwe-histopathological.
Imiphumela yokugcina yokuhlola ibonise ukuthi uma kuqhathaniswa nokuchayeka entuthuni kagwayi, amagundane achayeka ku-e-cigarette aerosols anama-flavour kanye nangenawo ayengenazo izinguquko eziphawulekayo ezithweni zokuphefumula, ikhala, kanye nezicubu ze-laryngeal epithelial, ezibonisa ukuthi i-e-cigarettes I-sol ayicasuli kancane. kuzicubu nezitho ezihambisanayo.Imiphumela yokuhlolwa iphinde yafakazela ukuthi, uma kuqhathaniswa nogwayi wendabuko, i-e-cigarettes inganciphisa kakhulu ukuvuvukala kwamaphaphu, kanye nokulimala kwe-epithelium yekhala, umphimbo kanye noqhoqhoqho.
I-BAT British American Tobacco ishicilele iphepha locwaningo elinesihloko esithi "An Experimental Analytical and In Vitro Approach to Bridge between Different Heated Tobacco Product Variants" kujenali yesayensi "Iminikelo Yogwayi Nocwaningo LweNicotine", futhi yenza ucwaningo ngeTHP (imikhiqizo ye-HNB) Toxicology. ukuhlola.Ocwaningweni, intuthu ye-aerosol kanye nentuthu kagwayi yezinhlobonhlobo ezinhlanu ze-THP kanye ne-THP eyodwa eyisisekelo zisetshenziswe njengendawo yokuhlola, futhi i-cytotoxicity yahlolwa ngokusebenza kwamaseli e-epithelial yamaphaphu omuntu.Imiphumela yabonisa ukuthi konke ukusabela kwe-cytotoxic eqenjini le-THP bekungaphansi ngo-95% kunalezo eziseqenjini lentuthu kagwayi, futhi awukho umehluko obalulekile wobuthi phakathi kwama-THP amahlanu ahlukene kanye ne-THP eyisisekelo.
Ucwaningo luphethe ngokuthi ukuthuthukiswa nokuhlinzekwa kweminye imikhiqizo kagwayi ne-nicotine kukhula ngokushesha, abathengi baya ngokuya bemukela imikhiqizo emisha efana ne-THP, futhi ukuphepha kwayo kanye nobungozi njengengxenye yokuhlola okunobuthi kufanele ukunakwa kwemboni.Kuphela uma umkhiqizo ufinyelela amazinga (okuhlanganisa nokusebenza kwebhethri) lapho ungadlala indima yawo enhle njengesu lezempilo lomphakathi.
Izithenjwa:
U-Ee Tsin Wong, uKarsta Luettich, uLydia Cammack, nabanye.Ukuhlolwa kobuthi bokuhogela bentuthu kagwayi nama-aerosol avela ezixubeni zokunambitheka: Ucwaningo lwamaviki angu-5 kumagundane e-A/J.Ijenali ye-toxicolog esetshenzisiwe, 2022
U-Tomasz Jaunky, uDavid Thorne, u-Andrew Baxter, nabanye.Indlela Yokuhlola Yokuhlola kanye Ne-In Vitro Yebhuloho Phakathi Kwezinhlobonhlobo Ezihlukene Zomkhiqizo Kagwayi Oshisayo.Iminikelo Yokucwaninga Ngogwayi Ne-Nicotine, 2022.
Isikhathi sokuthumela: Feb-01-2023
